The FDA has warned consumers that certain drugs for erectile dysfunction (ED) and premature ejaculation (PE) can have potential side effects, including heart risks and gastrointestinal disorders. A study published in the November, 2018, issue of the American Journal of Medicine indicated that sildenafil and tadalafil can cause fewer heart-related side effects than Viagra and Cialis.
The study found that sildenafil and tadalafil may also lower blood pressure in some men, but they did not provide an indication that they could be a risk.
In a review article published in the February, 2017, issue of the American Journal of Medicine, researchers looked at the side effects of three commonly used drugs, including Viagra, Cialis, and Levitra, and found no risk.
Sildenafil and tadalafil are the two drugs used to treat ED and PE, but they each carry the risk of heart problems, a heart attack or stroke, and a low blood pressure.
Viagra (sildenafil citrate) and Cialis (tadalafil) belong to a class of medications called phosphodiesterase 5 (PDE5) inhibitors.
Levitra (vardenafil) is another class of PDE5 inhibitor, and it was found to be slightly more likely to cause lower blood pressure in a small number of men than Viagra and Cialis, which are used to treat erectile dysfunction (ED).
The risk of these side effects is higher for men taking sildenafil, tadalafil, and avanafil, the researchers note.
These medications work by relaxing the muscles in the blood vessels that supply the penis, causing increased blood flow and facilitating an erection. Viagra and Cialis are also known to have fewer heart-related side effects than other PDE5 inhibitors.
In a, researchers analyzed data from the medical records of more than 50,000 patients in the United States.
The findings showed that the medication sildenafil, taken as a daily low dose, lowered blood pressure in 81 percent of men taking Viagra, but sildenafil and tadalafil increased the risk of heart problems. Viagra and Cialis also lowered blood pressure, according to the study.
Both sildenafil and tadalafil have been found to have potential side effects.
The study, which was published in theJournal of the American Medical Association, examined the side effects of Viagra and Cialis in patients taking one of these medications for erectile dysfunction. The researchers looked at a total of 10,941 patients with ED and 5,638 patients with PE.
Overall, the researchers found that the sildenafil and tadalafil use was associated with an increased risk of these side effects compared to the other PDE5 inhibitors, which were not included in the study.
In addition, the researchers also looked at a larger number of patients taking a combined oral and an intravenous medication, which is similar to a heart attack or stroke prevention pill that was found to be more likely to occur in patients taking sildenafil, tadalafil, or avanafil.
Overall, they found that the use of sildenafil, tadalafil, and avanafil had an increased risk of heart problems, compared to the other PDE5 inhibitors, although these were not included in the study.
Sildenafil, tadalafil, and avanafil are PDE5 inhibitors that relax the muscles in the blood vessels, increasing blood flow, and facilitating an erection. The researchers also found no risk of low blood pressure in patients taking sildenafil, tadalafil, and avanafil, the medications used to treat erectile dysfunction (ED) or premature ejaculation (PE) at the time of the study.
The researchers also found no risk of heart-related side effects in patients taking sildenafil, tadalafil, and avanafil.
In addition, sildenafil and tadalafil have been found to be safe and well-tolerated in the United States, according to the researchers.
Amlodipine, a drug for treating erectile dysfunction in men
Amlodipine is a prescription medication that is prescribed for treating erectile dysfunction in men. It is a non-addictive drug that is a part of a group of medicines called phosphodiesterase type 5 (PDE5) inhibitors. This medication helps the penis muscles relax, which helps to improve blood flow to the penis. This medicine can be used to treat a variety of conditions like Pulmonary Hypertension, Benign Prostatic Hyperplasia (BPH), and Pulmonary Arterial Hypertension.
Amlodipine is also used to treat high blood pressure in the lungs, such as Pulmonary Arterial Hypertension. This medication is also used to treat pulmonary arterial hypertension (PAH) and severe hypertension in people with heart disease.
What does it do?
Amlodipine works by increasing blood flow to the penis, making it easier to get and maintain an erection. This can help to relax the blood vessels in the lungs, which can help to relax blood pressure and improve blood flow to the lungs.
It can be used to treat high blood pressure in the lungs, such as PAH and high blood pressure in the heart (HF). This medication works by increasing blood flow to the lungs and reducing blood pressure in the lungs.
Amlodipine is only effective when used as a short-term treatment. If you are taking this medication, it may not work as well for you. However, if you are not sure, talk to your doctor or pharmacist before taking this medication.
What are some side effects?
Amlodipine can cause some side effects in some people. These side effects include headache, dizziness, stomach cramps, diarrhea, nausea, and vomiting. If you experience any of these symptoms, stop taking this medication and talk to your doctor or pharmacist.
Other side effects may also occur if you experience side effects while taking this medication. These may include headaches, facial flushing, indigestion, and muscle aches. If you experience any of these side effects while taking this medication, stop taking this medication and seek medical attention.
How long does it take for this medicine to work?
Amlodipine may take a few weeks to become effective. If you have taken this medication for a long time, you may experience some side effects. These side effects may include:
If you experience these side effects while taking this medication, stop taking this medication and seek medical attention.
Do not take this medicine if you are allergic to it or to sildenafil or any other ingredient in this medicine
It is not known if this medication is safe for you to use if you are taking nitrates, or using other medicines for chest pain.
Do not take this medicine if you have heart problems, including unstable angina, severe heart failure, or uncontrolled high blood pressure
If you are not sure, talk to your doctor or pharmacist before taking this medication.
Do not give this medicine to children, adolescents, or people with a known hypersensitivity to sildenafil, or any other ingredients in this medicine
Amlodipine may cause an increased risk of blood clots in your penis. This risk is also increased with long-term use. Talk to your doctor before using this medicine if you are taking nitrates or any other medicines for chest pain.
Sildenafil citrate, commonly known by the brand name, is a prescription-only medicine used to treat erectile dysfunction (ED) in adult men. It works by improving blood flow to the penis, helping to achieve and maintain an erection during sexual activity.
Sildenafil is available in 25mg, 50mg, and 100mg strengths.
Sildenafil has been shown to be effective in up to 80% of men with ED, with effects typically noticeable within 30 to 60 minutes, and lasting for up to 4–5 hours.
Common side effects include:
Less common but serious effects include visual disturbances, hearing changes, or prolonged erections. Seek medical attention if severe or persistent side effects occur.
Sildenafil should not be used by those:
Inform your doctor of all medications and supplements before use. Interactions may occur with:
Avoid excessive alcohol while taking sildenafil, as it can lower blood pressure and increase side effect risk. Use with caution if you have any heart-related conditions.
Sildenafil is available by prescription only in the UK.
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Read More Close CommunicationSildenafil citrate, commonly known by the brand name, is a prescription-only medicine used to treat erectile dysfunction (ED) in adult men. It works by improving blood flow to the penis, helping to achieve and maintain an erection during sexual activity.
Sildenafil is available in 25mg, 50mg, and 100mg strengths.
Sildenafil has been shown to be effective in up to 80% of men with ED, with effects typically noticeable within 30 to 60 minutes, and lasting for up to 4–5 hours.
Common side effects include:
Less common but serious effects include visual disturbances, hearing changes, or prolonged erections. Seek medical attention if severe or persistent side effects occur.
Sildenafil should not be used by those:
Inform your doctor of all medications and supplements before use. Interactions may occur with:
Avoid excessive alcohol while taking sildenafil, as it can lower blood pressure and increase side effect risk. Use with caution if you have any heart-related conditions.
Sildenafil is available by prescription only in the UK.
Don’t let ED affect your confidence or relationships. Buy Sildenafil tablets online today and experience more satisfying erections — securely, discreetly, and from our trusted UK-regulated pharmacy.
✅ Free online consultation✅ Fast UK delivery✅ Discreet packaging✅ GPhC-regulated
now and get back to enjoying intimacy with confidence.
Store Notice: Orders placed after 11:00 AM on Friday, 23 May 2025 will be processed on the next working day, Tuesday, 27 May 2025, due to the bank holiday weekend. Thank you for your understanding.
Less common side effects but serious side effects include visual disturbances, hearing changes, or prolonged erections.
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